DRUGsmall molecule
4AP
Related claims (4)
| Type | Predicate | Conf | Source |
|---|---|---|---|
| motor function | 4-aminopyridine (4AP) can significantly increase twitch force and EMG of failing motor units in HCSMA homozygotes (observed in animal model). | 50% | PMID:9151766 |
| motor function | 4-aminopyridine (4AP) increases peak forces during motor unit tetanic activation but does not eliminate tetanic force failure in HCSMA homozygotes (observed in animal model). | 50% | PMID:9151766 |
| drug efficacy | The ability of 4-aminopyridine (4AP) to increase force in failing motor units may be related to the extent of motor unit failure (observed in animal model). | 42% | PMID:9151766 |
| drug efficacy | 4-aminopyridine (4AP) increases nerve-evoked whole muscle twitch force and electromyograms (EMG) to a greater extent in older homozygous HCSMA animals than in similarly aged, symptomless HCSMA animals or younger homozygous animals (observed... | 42% | PMID:9151766 |
Off-Target Findings (29)
T4: 1untiered: 28
| Target | Role | Tier | Boltz-2 iPTM | Chai-1 iPTM | Verdict |
|---|---|---|---|---|---|
| CHRNA1_ECD | OTHER | T4 | 0.938 | — | Low relevance |
| RIPK3_kinase | UNCLASSIFIED | — | 0.976 | — | — |
| LIMK2_aC | OTHER | — | 0.961 | — | — |
| PLS3_EF4 | OTHER | — | 0.876 | — | — |
| KCNA2_pore | OTHER | — | 0.874 | — | — |
| SMN1_YGbox | OTHER | — | 0.864 | — | — |
| AQP4_M1 | UNCLASSIFIED | — | 0.863 | — | — |
| CFL2 | SMA | — | 0.840 | — | — |
| LIMK1_aC | OTHER | — | 0.824 | — | — |
| PFN2 | SMA | — | 0.815 | — | — |
| STMN1 | SMA | — | 0.767 | — | — |
| ROCK2_aC | OTHER | — | 0.763 | — | — |
| EIF4E_capbinding | UNCLASSIFIED | — | 0.747 | — | — |
| S100B_dimer | UNCLASSIFIED | — | 0.741 | — | — |
| PERP_ECL1 | OTHER | — | 0.740 | — | — |
| DNMT3B_catalytic | UNCLASSIFIED | — | 0.730 | — | — |
| AGRN_LG3 | OTHER | — | 0.722 | — | — |
| GAP43 | SMA | — | 0.697 | — | — |
| HSP70_NBD | OTHER | — | 0.686 | — | — |
| RAPSN_nterm | OTHER | — | 0.666 | — | — |
| LRP4_propeller | OTHER | — | 0.653 | — | — |
| RIPK1_kinase | UNCLASSIFIED | — | 0.599 | — | — |
| ROCK1_aC | OTHER | — | 0.564 | — | — |
| MLKL_4HB | UNCLASSIFIED | — | 0.552 | — | — |
| NCALD | SMA | — | 0.547 | — | — |
| CFL1 | SMA | — | 0.527 | — | — |
| CLCN1_pore | UNCLASSIFIED | — | 0.500 | — | — |
| CHRNG_fetal | OTHER | — | 0.495 | — | — |
| DOK7_PH | OTHER | — | 0.468 | — | — |