SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
15,934Targets
453Trials
84Drugs
7Datasets
7,947Sources
226,991Claims
263,546Evidence
58,010Hypotheses
DRUGapprovedsmall molecule

ataluren

Approved indications

duchenne-muscular-dystrophy-nonsense

Related claims (0)

No claims matched “ataluren” in free-text search.

Off-Target Findings (227)

T1: 3T3: 212untiered: 12
TargetRoleTierBoltz-2 iPTMChai-1 iPTMVerdict
CHRNGion_channelSMAT10.766Primary SMA hit
KCNA2ion_channelSMAT10.655Primary SMA hit
SCN5Aion_channelSMAT10.402Primary SMA hit
RIPK2kinaseOFF-TARGETT30.985Selectivity flag (off-target substrate)
TGFBR1kinaseSMAT30.979Selectivity flag (off-target substrate)
ACVR2BkinaseSMAT30.972Selectivity flag (off-target substrate)
FGRkinaseOFF-TARGETT30.971Selectivity flag (off-target substrate)
P2RY6gpcrOFF-TARGETT30.968Selectivity flag (off-target substrate)
STK17BkinaseOFF-TARGETT30.961Selectivity flag (off-target substrate)
ADORA3gpcrOFF-TARGETT30.961Selectivity flag (off-target substrate)
MRGPRX1gpcrOFF-TARGETT30.960Selectivity flag (off-target substrate)
DYRK2kinaseOFF-TARGETT30.959Selectivity flag (off-target substrate)
MINK1kinaseOFF-TARGETT30.958Selectivity flag (off-target substrate)
MRGPRX4gpcrOFF-TARGETT30.958Selectivity flag (off-target substrate)
PTK6kinaseOFF-TARGETT30.957Selectivity flag (off-target substrate)
RPS6KA1kinaseOFF-TARGETT30.952Selectivity flag (off-target substrate)
CDC42BPAkinaseOFF-TARGETT30.948Selectivity flag (off-target substrate)
CITkinaseOFF-TARGETT30.945Selectivity flag (off-target substrate)
OXGR1gpcrOFF-TARGETT30.936Selectivity flag (off-target substrate)
CHEK1kinaseOFF-TARGETT30.934Selectivity flag (off-target substrate)
ERBB3kinaseOFF-TARGETT30.934Selectivity flag (off-target substrate)
FFAR1gpcrOFF-TARGETT30.934Selectivity flag (off-target substrate)
PIP4K2AkinaseOFF-TARGETT30.933Selectivity flag (off-target substrate)
GPR18gpcrOFF-TARGETT30.932Selectivity flag (off-target substrate)
GRK1kinaseOFF-TARGETT30.930Selectivity flag (off-target substrate)
MYLK3kinaseOFF-TARGETT30.928Selectivity flag (off-target substrate)
ERBB2kinaseOFF-TARGETT30.919Selectivity flag (off-target substrate)
PRKXkinaseOFF-TARGETT30.918Selectivity flag (off-target substrate)
STK10kinaseOFF-TARGETT30.914Selectivity flag (off-target substrate)
SCTRgpcrOFF-TARGETT30.905Selectivity flag (off-target substrate)
GPR135gpcrOFF-TARGETT30.903Selectivity flag (off-target substrate)
MAP3K3kinaseOFF-TARGETT30.901Selectivity flag (off-target substrate)
MAP3K13kinaseOFF-TARGETT30.900Selectivity flag (off-target substrate)
OPRL1gpcrOFF-TARGETT30.898Selectivity flag (off-target substrate)
TACR1gpcrOFF-TARGETT30.888Selectivity flag (off-target substrate)
CASKkinaseOFF-TARGETT30.888Selectivity flag (off-target substrate)
RPS6KA4kinaseOFF-TARGETT30.886Selectivity flag (off-target substrate)
CDK12kinaseOFF-TARGETT30.885Selectivity flag (off-target substrate)
MRGPRDgpcrOFF-TARGETT30.884Selectivity flag (off-target substrate)
PIK3CDkinaseOFF-TARGETT30.883Selectivity flag (off-target substrate)
SSTR4gpcrOFF-TARGETT30.879Selectivity flag (off-target substrate)
CCKBRgpcrOFF-TARGETT30.878Selectivity flag (off-target substrate)
FZD5gpcrOFF-TARGETT30.876Selectivity flag (off-target substrate)
CLK3kinaseOFF-TARGETT30.873Selectivity flag (off-target substrate)
BMXkinaseOFF-TARGETT30.872Selectivity flag (off-target substrate)
CDK11AkinaseOFF-TARGETT30.868Selectivity flag (off-target substrate)
HRH2gpcrOFF-TARGETT30.867Selectivity flag (off-target substrate)
OPRD1gpcrOFF-TARGETT30.865Selectivity flag (off-target substrate)
PDK2kinaseOFF-TARGETT30.862Selectivity flag (off-target substrate)
SSTR5gpcrOFF-TARGETT30.862Selectivity flag (off-target substrate)

Showing top 50 of 227 targets.

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