SMA Research Platform

Protein Structures

STRUCTURAL

70 structures

Predicted 3D structures for all SMA research targets using AlphaFold2, AlphaFold-3, ESMfold, and Boltz-2. Each structure is scored by pLDDT (predicted Local Distance Difference Test) — a per-residue confidence metric that tells you how reliable each part of the structure is for drug design.

pLDDT Confidence Interpretation

pLDDT ≥ 90: Very high confidence

Suitable for docking and structure-based drug design.

pLDDT 70–90: Confident

Backbone reliable. Usable for initial virtual screening.

pLDDT 50–70: Low confidence

Unreliable — often flexible loops or poorly conserved regions.

pLDDT < 50: Very low

Likely disordered. Do NOT use for docking.

Why this matters for SMA drug design:3D protein structure directly determines which pockets small molecules can bind. Use the “3D” button to visualize structures interactively.

Monomer structures via AlphaFold DB v6 (EMBL-EBI), ESMfold v1, and Boltz-2. Multi-chain complexes via AlphaFold-3 (alphafoldserver.com) — see AF3 viewer above. Method badges indicate prediction source. MW estimates: ~110 Da per residue.

Total Structures

pLDDT ≥90

pLDDT 70–90

pLDDT <70

High Druggability

78.4

Avg pLDDT

NEW · AlphaFold-3 Batch

Protein-Protein Complex Predictions (83 jobs)

Batch 20260429_02804 · 4 STRONG · 4borderline · LIMK2×CFL2 iPTM=0.80· PLS3-actin iPTM=0.76

View AF3 viewer →

AF3 predictions submitted to alphafoldserver.com. Multi-chain complexes (PPI / NMJ stoichiometry / regen-axis interactions) live on a separate page because the per-target index below shows one best monomer per gene.

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Symbol	UniProt	Source	pLDDT	Residues	Druggability	Binders	Molecules	Links
ABI2	Q9NYB9	AlphaFold DB	67.1	513	Low Confidence — Disordered Region	0	0	View 3D
ACTG1	P63261	AlphaFold DB	95.4	375	High Confidence — Druggable	0	0	View 3D
ACTR2	P61160	AlphaFold DB	94.0	394	High Confidence — Druggable	0	0	View 3D
AGRN	O00468	AlphaFold DB	69.8	2068	Low Confidence — Disordered Region	0	707	View 3D
ANK3	Q12955	AlphaFold DB	82.7	1000	Moderate Confidence — Assess Pocket	0	0	View 3D
BCL2	P10415	AlphaFold DB	74.2	239	Moderate Confidence — Assess Pocket	0	0	View 3D
BCL2L1	Q07817	AlphaFold DB	73.3	233	Moderate Confidence — Assess Pocket	0	0	View 3D
BDNF	P23560	AlphaFold DB	71.4	247	Moderate Confidence — Assess Pocket	0	0	View 3D
C1QA	P02745	AlphaFold DB	83.7	245	Moderate Confidence — Assess Pocket	0	0	View 3D
CASP3	P42574	AlphaFold DB	86.6	277	High Confidence — Druggable	1	50	View 3D
CASP9	P55211	AlphaFold DB	80.9	416	Moderate Confidence — Assess Pocket	1	50	View 3D
CAST	O15446	AlphaFold DB	55.7	510	Low Confidence — Disordered Region	0	0	View 3D
CD44	P16070	AlphaFold DB	53.3	742	Low Confidence — Disordered Region	0	0	View 3D
CDC42	P60953	ESMfold NIM	89.7	191	High Confidence — Druggable	0	283	View 3D
CFL1	P23528	ESMfold NIM	85.0	166	High Confidence — Druggable	0	643	View 3D
CFL2	Q9Y281	AlphaFold DB	88.8	166	High Confidence — Druggable	1	1008	View 3D
CHAT	P28329	ESMfold NIM	85.5	748	High Confidence — Druggable	0	0	View 3D
CHRNA1	P02708	AlphaFold DB	84.3	457	Moderate Confidence — Assess Pocket	0	0	View 3D
CNTF	P26441	AlphaFold DB	85.8	200	High Confidence — Druggable	0	0	View 3D
CORO1C	Q9ULV4	AlphaFold DB	91.1	474	High Confidence — Druggable	1	708	View 3D
CTNNA1	P35221	AlphaFold DB	83.0	906	Moderate Confidence — Assess Pocket	0	0	View 3D
DNMT3B	Q9UBC3	AlphaFold DB	73.2	853	Moderate Confidence — Assess Pocket	0	0	View 3D
ETV1	P50549	ESMfold NIM	53.4	477	Low Confidence — Disordered Region	0	0	View 3D
FST	P19883	AlphaFold DB	87.8	344	High Confidence — Druggable	0	0	View 3D
FUS	P35637	AlphaFold DB	55.0	526	Low Confidence — Disordered Region	0	0	View 3D
GALNT6	Q8NCL4	AlphaFold DB	88.6	622	High Confidence — Druggable	0	0	View 3D
GDNF	P39905	AlphaFold DB	75.3	211	Moderate Confidence — Assess Pocket	0	0	View 3D
HTRA2	O43464	AlphaFold DB	74.8	458	Moderate Confidence — Assess Pocket	0	0	View 3D
IGF1	P05019	AlphaFold DB	59.7	195	Low Confidence — Disordered Region	0	0	View 3D
LDHA	P00338	AlphaFold DB	96.1	332	High Confidence — Druggable	1	50	View 3D
LIMK1	P53667	AlphaFold DB	76.1	647	Moderate Confidence — Assess Pocket	5	1282	View 3D
LIMK2	P53671	ESMfold NIM	78.2	638	Moderate Confidence — Assess Pocket	11	8731	View 3D
LRPN4	Q6UXI1	AlphaFold DB	75.4	379	Moderate Confidence — Assess Pocket	0	0	View 3D
LY96	Q9Y6Y9	AlphaFold DB	87.7	160	High Confidence — Druggable	0	0	View 3D
MAPK14	Q16539	AlphaFold DB	89.9	360	High Confidence — Druggable	5	50	View 3D
MDM2	Q00987	AlphaFold DB	63.2	491	Low Confidence — Disordered Region	1	50	View 3D
MDM4	O15151	AlphaFold DB	60.8	490	Low Confidence — Disordered Region	0	0	View 3D
MSTN	O14793	AlphaFold DB	78.8	375	Moderate Confidence — Assess Pocket	0	0	View 3D
MUSK	O15146	AlphaFold DB	76.6	869	Moderate Confidence — Assess Pocket	0	637	View 3D
NCALD	P61601	AlphaFold DB	86.9	193	High Confidence — Druggable	1	887	View 3D
NEDD4L	Q96PU5	AlphaFold DB	69.8	975	Low Confidence — Disordered Region	0	0	View 3D
NEFH	P12036	AlphaFold DB	54.3	1020	Low Confidence — Disordered Region	0	0	View 3D
NEFL	P07196	AlphaFold DB	73.7	543	Moderate Confidence — Assess Pocket	0	0	View 3D
PAK1	Q13153	ESMfold NIM	80.8	545	Moderate Confidence — Assess Pocket	1	58	View 3D
PAK4	O96013	ESMfold NIM	74.3	591	Moderate Confidence — Assess Pocket	0	0	View 3D
PFN1	P07737	AlphaFold DB	95.7	140	High Confidence — Druggable	0	668	View 3D
PFN2	P35080	ESMfold NIM	89.2	140	High Confidence — Druggable	1	759	View 3D
PLS3	P13797	AlphaFold DB	89.0	630	High Confidence — Druggable	1	375	View 3D
PTEN	P60484	ESMfold NIM	83.4	403	Moderate Confidence — Assess Pocket	0	0	View 3D
PVALB	P20472	ESMfold NIM	92.9	110	High Confidence — Druggable	0	0	View 3D
RAC1	P63000	ESMfold NIM	90.8	192	High Confidence — Druggable	1	273	View 3D
RAPSN	Q13702	AlphaFold DB	93.3	412	High Confidence — Druggable	0	816	View 3D
RHOA	P61586	ESMfold NIM	89.8	193	High Confidence — Druggable	0	0	View 3D
RIPK1	Q13546	AlphaFold DB	70.4	671	Moderate Confidence — Assess Pocket	0	30	View 3D
RND3	P61587	ESMfold NIM	91.8	244	High Confidence — Druggable	0	0	View 3D
ROCK2	O75116	AlphaFold DB	76.8	1388	Moderate Confidence — Assess Pocket	15	854	View 3D
RUNX3	Q13761	ESMfold NIM	58.5	415	Low Confidence — Disordered Region	0	0	View 3D
SARM1	Q6SZW1	AlphaFold DB	86.5	724	High Confidence — Druggable	0	28	View 3D
SETX	Q7Z333	AlphaFold DB	52.9	2677	Low Confidence — Disordered Region	0	0	View 3D
SLC17A7	Q9P2U7	ESMfold NIM	90.1	560	High Confidence — Druggable	0	0	View 3D
SMN1	Q16637	AlphaFold DB	67.4	294	Low Confidence — Disordered Region	1	758	View 3D
SMN2	Q16637	AlphaFold DB	67.4	294	Low Confidence — Disordered Region	1	1004	View 3D
SPATA18	Q8TC71	AlphaFold DB	75.5	538	Moderate Confidence — Assess Pocket	0	0	View 3D
STMN2	Q93045	AlphaFold DB	85.9	179	High Confidence — Druggable	1	929	View 3D
SULF1	Q8IWU6	AlphaFold DB	74.3	871	Moderate Confidence — Assess Pocket	0	0	View 3D
TARDBP	Q13148	AlphaFold DB	66.5	414	Low Confidence — Disordered Region	0	0	View 3D
TMEM41B	Q5BJD5	AlphaFold DB	82.8	291	Moderate Confidence — Assess Pocket	0	0	View 3D
TP53	P04637	AlphaFold DB	75.8	393	Moderate Confidence — Assess Pocket	1	271	View 3D
UBA1	P22314	AlphaFold DB	92.7	1058	High Confidence — Druggable	1	2244	View 3D
ZPR1	O75312	AlphaFold DB	80.1	459	Moderate Confidence — Assess Pocket	0	0	View 3D