SMA Research Platform

Evidence graph for Spinal Muscular Atrophy

Biology-first target discovery
Christian Fischer / Bryzant Labs
15,934Targets
453Trials
84Drugs
7Datasets
7,947Sources
227,510Claims
263,546Evidence
58,010Hypotheses

OpenFold-3 Structure Predictions

COMPUTATIONAL
← All AF3 results · 192 jobs · 16 strong · 87 borderline

OpenFold3 is NVIDIA's NIM-hosted alternative to AlphaFold3 — used for high-throughput binder validation (LIMK2, ROCK2 candidates) where AF3 server is rate-limited or paused.

OpenFold-3 predictions executed via NVIDIA NIM for cross-validation of protein-protein interfaces in the SMA pathology graph. Each job produces 1 model; we report iPTM, PTM, and ranking_score. iPTM ≥ 0.85 indicates high- confidence interface; 0.70–0.85 strong, 0.50–0.70 borderline, <0.50 weak/refuted.

JobiPTMPTMRankTierModelsSource
ppi_hif1a_18_80_tp53_323_3560.8020.7671.027STRONG1/1OpenFold3 NIM
ppi_smn1_260_294_tsc2_876_11260.7960.6870.937STRONG1/1OpenFold3 NIM
binder_limk2_job_0_n_4240.7630.7880.785STRONG1/1OpenFold3 NIM
ppi_pak1_87_200_tp53_323_3560.7580.6451.039STRONG1/1OpenFold3 NIM
ppi_pak1_87_200_tp53_323_356_consensus_v30.7560.6361.032STRONG1/1OpenFold3 NIM
ppi_pak1_74_149_tp53_323_3560.7520.7851.031STRONG1/1OpenFold3 NIM
ppi_hif1a_18_80_smn1_260_294_consensus_v30.7450.7700.872STRONG1/1OpenFold3 NIM
ppi_atf3_none_none_tp53_323_3560.7420.5840.899STRONG1/1OpenFold3 NIM
ppi_mdm2_17_125_smn1_260_2940.7410.7310.947STRONG1/1OpenFold3 NIM
ppi_hif1a_18_80_smn1_260_2940.7410.7700.854STRONG1/1OpenFold3 NIM
binder_rock2_job_0_n_414_id_1_bon_orig0_r10.7400.6620.725STRONG1/1OpenFold3 NIM
ppi_hif1a_18_80_hnrnpa1_106_1840.7200.7230.724STRONG1/1OpenFold3 NIM
ppi_pak1_74_149_tp53_363_3930.7090.7750.928STRONG1/1OpenFold3 NIM
ppi_hif1a_18_80_tardbp_104_1760.7090.7230.778STRONG1/1OpenFold3 NIM
ppi_chrna1_220_445_tp53_323_3560.7060.7040.758STRONG1/1OpenFold3 NIM
ppi_hnrnpa1_15_93_smn1_260_2940.7050.7430.792STRONG1/1OpenFold3 NIM
ppi_pak1_74_149_ptk2_914_10520.6990.7780.759borderline1/1OpenFold3 NIM
ppi_limk2_165_280_tp53_323_3560.6930.5940.966borderline1/1OpenFold3 NIM
ppi_deptor_322_409_mtor_1251_15010.6910.7000.692borderline1/1OpenFold3 NIM
ppi_rock2_941_1010_stmn1_none_none0.6880.5800.927borderline1/1OpenFold3 NIM
ppi_smn1_90_159_tp53_363_3930.6870.7060.844borderline1/1OpenFold3 NIM
ppi_nrg1_176_246_tp53_323_3560.6850.6620.956borderline1/1OpenFold3 NIM
ppi_rock2_941_1010_tp53_363_3930.6840.7150.982borderline1/1OpenFold3 NIM
ppi_pak1_74_149_tp53_1_620.6750.7150.919borderline1/1OpenFold3 NIM
ppi_smn1_260_294_smn1_90_1590.6720.7360.699borderline1/1OpenFold3 NIM
ppi_kcna2_pore_perp_ecl10.6700.7000.850borderline1/1OpenFold3 NIM
ppi_rock1_948_1015_wasf1_445_5590.6690.5630.929borderline1/1OpenFold3 NIM
ppi_hnrnpa1_106_184_smn1_260_2940.6660.6630.819borderline1/1OpenFold3 NIM
ppi_perp_ecl1_pls3_ef40.6660.6660.875borderline1/1OpenFold3 NIM
ppi_ncald_none_none_pak1_74_1490.6650.7550.703borderline1/1OpenFold3 NIM
ppi_hif1a_18_80_tp53_1_620.6640.7000.991borderline1/1OpenFold3 NIM
ppi_hif1a_18_80_tp53_363_3930.6600.7350.904borderline1/1OpenFold3 NIM
ppi_nrg1_176_246_tardbp_104_1760.6590.6990.698borderline1/1OpenFold3 NIM
ppi_limk1_165_280_wasf1_445_5590.6550.5640.853borderline1/1OpenFold3 NIM
ppi_gfra1_146_265_musk_310_4950.6470.6370.709borderline1/1OpenFold3 NIM
ppi_rock2_941_1010_tp53_1_620.6470.6740.861borderline1/1OpenFold3 NIM
ppi_limk1_165_280_nrg1_176_2460.6460.5930.817borderline1/1OpenFold3 NIM
ppi_hnrnpa1_106_184_tp53_363_3930.6440.6440.803borderline1/1OpenFold3 NIM
ppi_dok7_1_100_limk2_165_2800.6390.6590.707borderline1/1OpenFold3 NIM
ppi_bdnf_none_none_tp53_323_3560.6370.5740.685borderline1/1OpenFold3 NIM
ppi_pls3_300_630_smn1_260_2940.6370.6530.662borderline1/1OpenFold3 NIM
ppi_hnrnpa1_15_93_tp53_363_3930.6330.6430.826borderline1/1OpenFold3 NIM
ppi_atf3_none_none_rock2_941_10100.6300.6130.736borderline1/1OpenFold3 NIM
ppi_agrn_130_300_mdm2_17_1250.6270.6770.664borderline1/1OpenFold3 NIM
ppi_limk1_165_280_tp53_323_3560.6250.6170.853borderline1/1OpenFold3 NIM
ppi_atf3_none_none_pak1_74_1490.6240.5740.647borderline1/1OpenFold3 NIM
ppi_pak1_74_149_stmn2_none_none0.6160.5310.750borderline1/1OpenFold3 NIM
ppi_smn1_260_294_tsc2_1001_12510.6140.5890.777borderline1/1OpenFold3 NIM
binder_rock2_job_0_n_334_id_0_bon_orig2_r00.6110.6160.612borderline1/1OpenFold3 NIM
ppi_nrg1_176_246_stmn1_none_none0.6110.5400.769borderline1/1OpenFold3 NIM
ppi_mtor_126_376_tardbp_104_1760.6100.5820.605borderline1/1OpenFold3 NIM
ppi_nrg1_176_246_smn1_90_1590.6100.6600.677borderline1/1OpenFold3 NIM
ppi_limk1_165_280_musk_495_5750.6090.6370.774borderline1/1OpenFold3 NIM
ppi_nrg1_176_246_tp53_1_620.6090.6500.854borderline1/1OpenFold3 NIM
ppi_nrg1_176_246_smn1_260_2940.5990.6540.704borderline1/1OpenFold3 NIM
ppi_smn1_260_294_tsc2_751_10010.5970.6600.686borderline1/1OpenFold3 NIM
ppi_smn1_260_294_tp53_363_3930.5960.6480.849borderline1/1OpenFold3 NIM
ppi_raptor_626_876_smn1_260_2940.5900.6300.780borderline1/1OpenFold3 NIM
ppi_tardbp_104_176_tp53_1_620.5850.6280.698borderline1/1OpenFold3 NIM
ppi_gdnf_none_none_hif1a_18_800.5840.5720.797borderline1/1OpenFold3 NIM
ppi_smn1_90_159_tp53_1_620.5810.6740.835borderline1/1OpenFold3 NIM
ppi_tardbp_193_262_tp53_363_3930.5810.6270.744borderline1/1OpenFold3 NIM
ppi_dok7_1_100_tp53_363_3930.5810.6620.715borderline1/1OpenFold3 NIM
ppi_agrn_1_130_ncald_none_none0.5800.6700.623borderline1/1OpenFold3 NIM
ppi_hif1a_18_80_mdm2_17_1250.5790.6430.728borderline1/1OpenFold3 NIM
ppi_smn1_260_294_tp53_323_3560.5690.6550.753borderline1/1OpenFold3 NIM
ppi_limk2_165_280_tp53_1_620.5680.5890.685borderline1/1OpenFold3 NIM
ppi_mtor_1251_1501_smn1_260_2940.5610.6100.620borderline1/1OpenFold3 NIM
ppi_mtor_1626_1876_smn1_260_2940.5590.5850.721borderline1/1OpenFold3 NIM
ppi_musk_495_575_ncald_none_none0.5580.6450.623borderline1/1OpenFold3 NIM
ppi_rictor_1376_1626_smn1_90_1590.5570.5860.563borderline1/1OpenFold3 NIM
ppi_tardbp_104_176_tp53_363_3930.5570.6570.726borderline1/1OpenFold3 NIM
ppi_deptor_322_409_smn1_260_2940.5530.6140.618borderline1/1OpenFold3 NIM
ppi_srsf1_16_90_tp53_363_3930.5510.6200.711borderline1/1OpenFold3 NIM
ppi_deptor_none_none_smn1_260_2940.5470.4540.555borderline1/1OpenFold3 NIM
ppi_limk1_165_280_tp53_1_620.5460.5410.727borderline1/1OpenFold3 NIM
ppi_musk_310_495_ntrk3_196_2820.5440.6300.625borderline1/1OpenFold3 NIM
ppi_agrn_1_130_pak1_74_1490.5410.6150.621borderline1/1OpenFold3 NIM
ppi_raptor_626_876_tardbp_104_1760.5380.5790.699borderline1/1OpenFold3 NIM
ppi_mtor_2126_2376_smn1_260_2940.5380.5320.607borderline1/1OpenFold3 NIM
ppi_smn1_260_294_tardbp_193_2620.5360.5720.786borderline1/1OpenFold3 NIM
ppi_hnrnpa1_15_93_tp53_1_620.5360.6590.593borderline1/1OpenFold3 NIM
ppi_agrn_1_130_tp53_323_3560.5340.5840.693borderline1/1OpenFold3 NIM
ppi_limk2_165_280_tp53_363_3930.5330.5750.796borderline1/1OpenFold3 NIM
ppi_cfl2_none_none_limk2_330_6380.5310.6280.550borderline1/1OpenFold3 NIM
ppi_smn1_260_294_stmn2_none_none0.5310.4690.775borderline1/1OpenFold3 NIM
ppi_atf3_none_none_dok7_1_1000.5260.4440.588borderline1/1OpenFold3 NIM
ppi_gfra1_146_265_lrp4_1656_19050.5230.4430.728borderline1/1OpenFold3 NIM
ppi_limk1_165_280_musk_310_4950.5200.5230.714borderline1/1OpenFold3 NIM
ternary_smn1_snrpa_chembl14838280.5190.5400.693borderline1/1OpenFold3 NIM
ppi_atf3_none_none_smn1_260_2940.5180.4610.694borderline1/1OpenFold3 NIM
ternary_smn2_snrpa_chembl14838280.5160.5290.697borderline1/1OpenFold3 NIM
ppi_nrg1_176_246_pak1_87_2000.5130.4830.661borderline1/1OpenFold3 NIM
ppi_limk1_165_280_tp53_363_3930.5110.5440.810borderline1/1OpenFold3 NIM
ppi_hnrnpa1_106_184_smn1_90_1590.5110.5760.524borderline1/1OpenFold3 NIM
ternary_smn2_snrpa_chembl13039980.5090.5300.685borderline1/1OpenFold3 NIM
ppi_fus_471_526_smn1_260_2940.5080.4670.572borderline1/1OpenFold3 NIM
ppi_smn1_260_294_stmn1_none_none0.5080.4440.778borderline1/1OpenFold3 NIM
ternary_smn2_snrpa_mmp_1303998_glycol0.5030.5270.682borderline1/1OpenFold3 NIM
ternary_smn2_snrpa_mmp_1303998_2pyridyl0.5020.5290.680borderline1/1OpenFold3 NIM
ppi_cfl1_none_none_rock1_948_10150.5010.5340.595borderline1/1OpenFold3 NIM
ternary_smn1_snrpa_chembl15778580.5010.5220.679borderline1/1OpenFold3 NIM
ppi_agrn_876_1126_gfra3_132_2550.5010.5620.596borderline1/1OpenFold3 NIM
ppi_pak1_87_200_tp53_363_3930.4950.4750.798weak1/1OpenFold3 NIM
ppi_agrn_1_130_stmn2_none_none0.4950.4360.770weak1/1OpenFold3 NIM
ppi_gfra3_132_255_lrp4_1656_19050.4930.4880.678weak1/1OpenFold3 NIM
ternary_smn2_snrpa_mmp_1303998_2thienyl0.4910.5160.667weak1/1OpenFold3 NIM
ternary_smn2_snrpa_chembl15778580.4900.5170.669weak1/1OpenFold3 NIM
ppi_pik3ca_696_1068_smn1_90_1590.4850.4440.481weak1/1OpenFold3 NIM
ppi_cfl2_none_none_limk1_330_6470.4840.5650.500weak1/1OpenFold3 NIM
ppi_tardbp_104_176_tsc2_1_2510.4820.4830.482weak1/1OpenFold3 NIM
ppi_gdnf_none_none_smn1_260_2940.4790.4070.621weak1/1OpenFold3 NIM
ppi_ncald_none_none_rock1_948_10150.4770.5390.516weak1/1OpenFold3 NIM
ternary_smn1_snrpa_chembl15280690.4760.4780.678weak1/1OpenFold3 NIM
ppi_agrn_130_300_tp53_363_3930.4760.5700.592weak1/1OpenFold3 NIM
ternary_smn2_snrpa_mmp_1303998_ether0.4760.5030.661weak1/1OpenFold3 NIM
ppi_cfl1_none_none_pak1_74_1490.4760.5020.506weak1/1OpenFold3 NIM
ppi_stmn2_none_none_tp53_363_3930.4730.4680.708weak1/1OpenFold3 NIM
ppi_atf3_none_none_tardbp_193_2620.4730.3920.612weak1/1OpenFold3 NIM
ppi_srsf1_16_90_stmn2_none_none0.4710.4110.601weak1/1OpenFold3 NIM
ternary_smn2_snrpa_chembl15280690.4670.4940.646weak1/1OpenFold3 NIM
ppi_smn1_260_294_smn1_none_none0.4660.4210.659weak1/1OpenFold3 NIM
ppi_hnrnpa1_106_184_tp53_1_620.4650.5660.574weak1/1OpenFold3 NIM
ppi_cfl1_none_none_nrg1_176_2460.4650.5840.489weak1/1OpenFold3 NIM
ppi_agrn_1577_1782_tp53_1_620.4600.5650.597weak1/1OpenFold3 NIM
ppi_agrn_130_300_limk1_165_2800.4600.4990.588weak1/1OpenFold3 NIM
binder_rock2_job_0_n_334_id_1_bon_orig2_r10.4600.6160.491weak1/1OpenFold3 NIM
ppi_rheb_none_none_smn1_260_2940.4580.4920.572weak1/1OpenFold3 NIM
ppi_lrp4_1656_1905_mdm2_17_1250.4580.4720.625weak1/1OpenFold3 NIM
ppi_snrpd1_none_none_tp53_363_3930.4550.5000.644weak1/1OpenFold3 NIM
ternary_smn2_snrpa_chembl14662540.4540.4730.646weak1/1OpenFold3 NIM
ppi_cfl1_none_none_ncald_none_none0.4530.5540.486weak1/1OpenFold3 NIM
ppi_mtor_1626_1876_mtor_1876_21260.4530.4910.500weak1/1OpenFold3 NIM
ppi_atf3_none_none_srsf1_16_900.4500.4150.498weak1/1OpenFold3 NIM
ppi_smn1_90_159_snrpd1_none_none0.4440.5070.549weak1/1OpenFold3 NIM
ppi_bcl2l1_none_none_smn1_260_2940.4420.5270.635weak1/1OpenFold3 NIM
ppi_bcl2_none_none_smn1_260_2940.4340.4810.606weak1/1OpenFold3 NIM
smn1_x_bcl20.4340.4470.609weak1/1OpenFold3 NIM
ternary_smn1_snrpa_chembl14662540.4320.4610.635weak1/1OpenFold3 NIM
ppi_gemin2_none_none_smn1_260_2940.4270.4750.448weak1/1OpenFold3 NIM
ppi_rictor_1376_1626_stmn2_none_none0.4270.5020.494weak1/1OpenFold3 NIM
ppi_gdnf_none_none_tp53_323_3560.4260.3870.579weak1/1OpenFold3 NIM
ternary_smn2_snrpa_chembl4752440.4220.4560.625weak1/1OpenFold3 NIM
ternary_smn2_snrpa_mmp_1303998_3pyridyl0.4200.4610.631weak1/1OpenFold3 NIM
rheb_x_smn10.4180.4360.548weak1/1OpenFold3 NIM
ppi_bcl2_none_none_pak1_74_1490.4120.4700.574weak1/1OpenFold3 NIM
ppi_agrn_1_130_tp53_363_3930.4070.5080.614weak1/1OpenFold3 NIM
ppi_smn1_90_159_srsf1_none_none0.4070.3610.553weak1/1OpenFold3 NIM
ppi_limk2_165_280_lrp4_1656_19050.4050.4140.605weak1/1OpenFold3 NIM
ppi_mtor_376_626_smn1_260_2940.3930.4710.465weak1/1OpenFold3 NIM
ppi_cfl1_none_none_rictor_1126_13760.3910.4430.525weak1/1OpenFold3 NIM
ppi_fus_471_526_hnrnpa1_106_1840.3890.5770.567weak1/1OpenFold3 NIM
ppi_deptor_322_409_gdnf_none_none0.3830.4050.471weak1/1OpenFold3 NIM
ppi_cfl1_none_none_tp53_363_3930.3740.5270.483weak1/1OpenFold3 NIM
ppi_limk1_165_280_lrp4_1656_19050.3720.4130.514weak1/1OpenFold3 NIM
ternary_smn1_snrpa_chembl4752440.3650.4120.574weak1/1OpenFold3 NIM
ppi_musk_310_495_tp53_363_3930.3640.5060.549weak1/1OpenFold3 NIM
ppi_smn1_260_294_snrpd1_none_none0.3640.4410.600weak1/1OpenFold3 NIM
ppi_agrn_1391_1576_tp53_363_3930.3620.5660.474weak1/1OpenFold3 NIM
ppi_snrpd1_none_none_tp53_323_3560.3610.3960.590weak1/1OpenFold3 NIM
ppi_limk1_165_280_ntrk3_538_8250.3610.4680.414weak1/1OpenFold3 NIM
ppi_snrpd1_none_none_tp53_1_620.3520.4590.633weak1/1OpenFold3 NIM
ppi_gdnf_none_none_mtor_1126_13760.3480.3650.443weak1/1OpenFold3 NIM
ppi_atf3_none_none_gfra3_132_2550.3460.4200.466weak1/1OpenFold3 NIM
ppi_rock1_1100_1354_tp53_1_620.3440.4360.408weak1/1OpenFold3 NIM
ppi_pfn2_none_none_rapsn_none_none0.3350.3380.347weak1/1OpenFold3 NIM
ppi_lrp4_1656_1905_nrg1_176_2460.3340.3830.526weak1/1OpenFold3 NIM
ppi_bcl2_none_none_musk_310_4950.3310.4360.471weak1/1OpenFold3 NIM
ppi_igf1r_501_751_tsc2_1126_13760.3300.3700.347weak1/1OpenFold3 NIM
ppi_bdnf_none_none_limk1_165_2800.3210.4210.523weak1/1OpenFold3 NIM
ppi_pten_14_185_rictor_1126_13760.3160.3330.321weak1/1OpenFold3 NIM
ppi_musk_310_495_pfn2_none_none0.3140.4520.397weak1/1OpenFold3 NIM
stmn2_x_tp530.3090.3600.564weak1/1OpenFold3 NIM
ppi_limk1_330_647_tp53_363_3930.3090.6570.431weak1/1OpenFold3 NIM
ppi_mtor_1626_1876_srsf1_16_900.3090.4530.420weak1/1OpenFold3 NIM
ppi_stmn1_none_none_tsc2_1126_13760.3000.3660.566weak1/1OpenFold3 NIM
ppi_pfn1_none_none_ssh1_300_6000.2890.3950.409weak1/1OpenFold3 NIM
ppi_atf3_none_none_hnrnpa1_106_1840.2860.3750.308weak1/1OpenFold3 NIM
ppi_cfl2_none_none_tp53_1_620.2730.3460.423weak1/1OpenFold3 NIM
ppi_pak1_270_545_tp53_363_3930.2720.4780.364weak1/1OpenFold3 NIM
ppi_deptor_322_409_nrg1_176_2460.2710.5210.321weak1/1OpenFold3 NIM
ppi_rock1_948_1015_tp53_363_3930.2690.5520.603weak1/1OpenFold3 NIM
ppi_pls3_0_300_smn1_90_1590.2650.2730.267weak1/1OpenFold3 NIM
ppi_cfl1_none_none_limk1_330_6470.2630.3710.295weak1/1OpenFold3 NIM
ppi_klf6_none_none_limk2_165_2800.2510.3310.457weak1/1OpenFold3 NIM
ppi_atf3_none_none_cfl2_none_none0.2430.3470.304weak1/1OpenFold3 NIM
smn1_x_fus0.2350.2820.547weak1/1OpenFold3 NIM
nrg1_x_smn10.2340.3030.377weak1/1OpenFold3 NIM
ppi_deptor_none_none_mtor_1376_16260.2250.3060.279weak1/1OpenFold3 NIM
smn1_x_tp530.2230.2670.392weak1/1OpenFold3 NIM
ppi_cfl2_none_none_limk2_none_none0.2220.2840.235weak1/1OpenFold3 NIM
ppi_erbb4_1001_1251_lrp4_751_10010.2130.2690.388weak1/1OpenFold3 NIM
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